Cost effectiveness of becaplermin in the treatment of diabetic foot ulcers in four European countries

Modelling A Markov model was used to assess the clinical and economic outcomes associated with the two strategies under evaluation in a hypothetical cohort of patients with diabetic foot ulcers. The time horizon of the model was one year and the cycle length was one month. Patients entered the model with uninfected ulcers and, each month, moved across health states. The health states considered were uninfected ulcer, infected ulcer, gangrene, healed ulcer, amputation and death. The structure of the model was reported in the paper.